Rre NIK, here are a couple of thoughts. Curvemeister did need to be changed a bit for CS4, due to a change in the way that Photoshop handles its windows internally, it's possible that the NIK plugins are encountering a similar issue. TThe tabbed windows, in particular, were the ones that required changing Curvemeister, so try turiing off tabs. NIK is a very reputable software company, and I would make sure that you are up to date with any new revs that they may have. Also use the F key to rotate through Photoshop's various window modes.
This does not come from me, I suddenly found the "arrange documents" was not working I googled the problem and read the cure was to unistall the plugins which I did and everything was normal again. They could be older plugins because they came with my Wacom. I was not knocking NIK I know they are a good company.
I have tried, and just did again setting the points in RGB with the image also in RGB but it still acts the same way, the point follows the curser by about 1/4 inch unless I move very slowly, if I move the mouse or pen quickly alot of the time it just leaves the point behind.
I think I mentioned I have 2megs of ram with photoshop allotted 70%
Video card is ASUS Extreme AX800 XL 256mb 256 bit DDR PCI-E Duel DVI VIVO
Computer is getting older Sept. 2005 but has always been quite stable.
Hope this helps however please understand that this is just a hobby for me, sold my studio and photo business some years ago.